In the spring off 2021, the MIT Center for Collective Intelligence, MIT Media Lab’s Community Biotechnology Initiative, and MilliporeSigma—the life science business of Merck KGaA, Darmstadt, Germany—brought together a group of leaders in the biosciences and related disciplines, using an online platform and synchronous virtual events, to gain insights into key challenges the life sciences sector will face in coming years. The result will be brief reports on key topics addressed in the online exercise and a series of virtual Catalyst Conversations that delve into those topics in depth.